Sex Steroids and Bone

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In summary, free and bioavailable fraction levels of T and E2 in the circulation are associated positively, and SHBG level negatively, with the bone status of men until the end of their third decade of life and until the blood level of E2 begins to decline. The influence of gonadal steroids on bones in young adult men may depend on age and blood level of E2. Vermeulen A. A critical evaluation of simple methods for the estimation of free testosterone in serum.

J Clin Endocrinol Metab ; — Marcus R. The contribution of testosterone to skeletal development and maintenance: lessons from the androgen insensitivity syndrome.

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Colvard D. Identification of androgen receptors in normal human osteoblast-like cells. Vanderschueren D.

Gonadal sex steroid status and bone health in middle-aged and elderly European men. Osteoporos Int ; — Carani C. Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med ; 91— Chagin A. Genes of importance in the hormonal regulation of growth plate cartilage. Horm Res ; 71 Suppl. Smith E. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med ; — Recent experimental and clinical findings in the skeleton associated with loss of estrogen hormone or estrogen receptor activity. J Steroid Biochem Mol Biol ; — Baxter-Jones A.

International longitudinal pediatric reference standards for bone mineral content. Bone ; — Bonjour J. The importance and relevance of peak bone mass in the prevalence of osteoporosis. Salud Publica Mex ; 51 Suppl. Peak bone mass. Osteoporos Int ; 4 Suppl. Jackowski S.

Effect of maturational timing on bone mineral content accrual from childhood to adulthood: evidence from 15 years of longitudinal data. Kramek E. Blood lipids may have influence on the emotional well-being in young men.

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Health ; 2: — Van Pottelbergh I. Bioavailable estradiol and an aromatase gene polymorphism are determinants of bone mineral density changes in men over 70 years of age. Huhtaniemi I. Comparison of serum testosterone and estradiol measurements in European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men. Eur J Endocrinol ; — Khosla S. Comparison of sex steroid measurements in men by immunoassay versus mass spectroscopy and relationships with cortical and trabecular volumetric bone mineral density.

Ohlsson C. Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men.

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J Clin Endocrinol Metab ; E— Walsh J. Hormonal determinants of bone turnover before and after attainment of peak bone mass. Clin Endocrinol Oxf ; — Liu P. Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts. Brodie A. Aromatase expression in the human male. Mol Cell Endocrinol ; 23— Inoue T. The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis.

Mol Cell Endocrinol ; 35— Milewicz A. Endokrynol Pol ; 82— Ward K. Influence of age and sex steroids on bone density and geometry in middle-aged and elderly European men. Bjornerem A. Circulating sex steroids, sex hormone-binding globulin, and longitudinal changes in forearm bone mineral density in postmenopausal women and men: the Tromso study. Calcif Tissue Int ; 65— Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab a; — Legrand E. Bone ; 90— Lormeau C.

Sex hormone-binding globulin, estradiol, and bone turnover markers in male osteoporosis.

Abbreviations:

Gennari L. Longitudinal association between ex hormone levels, bone loss, and bone turnover in elderly men. Goderie-Plomp H.


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Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study. Relationship of chronic endurance exercise to the somatotropic and sex hormone status of older men.

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Harman S. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. Editorial: Sex hormone binding globulin: inhibitor or facilitator or both of sex steroid action? Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study.

Endokrynol Pol ; 65 5 : — Table I. Subject characteristics Tabela I. Table II. Hormone descriptives Tabela II. References 1. N Engl J Med ; — 8.